Criteria of Galsky et al That Make a Patient with Metastatic Urothelial Carcinoma Unfit for Cisplatin-Based Chemotherapy

 

Patient selection: metastatic urothelial carcinoma

 

Reasons why the patient may be "unfit" to receive cisplatin-based chemotherapy - one or more of the following:

(1) ECOG performance status 2 (or Karnofsky performance status 60-70%)

(2) creatinine clearance < 60 mL per minute

(3) Grade 2 to 4 audiometric hearing loss by the Common Terminology Criteria for Adverse Events version 4

(4) Grade 2 to 4 peripheral neuropathy by the Common Terminology Criteria for Adverse Events version 4

(5) NYHA Class III heart failure

 

where:

• ECOG PS 3 or 4 and NYHA Class IV are even more severe conditions..