Engert et al reported criteria for early stage Hodgkin's disease. A patient with early stage disease can be adequately managed using reduce treatment intensity. The authors are from the German Hodgkin Study Group and multiple institutions in Europe.
Patient selection: early Hodgkin's disease
Early stages:
(1) Stage IA
(2) Stage IB
(3) Stage IIA
(4) Stage IIB
Stage
Extent
B Symptoms
Number of Risk Factors
IA
single lymph node region; single extra nodal focus
0
0
IB
single lymph node region; single extra nodal focus
>= 1
0
IIA
2 or more lymph node regions or extra-nodal structures on the same side of the diaphragm
0
0
IIB
2 or more lymph node regions or extra-nodal structures on the same side of the diaphragm
>= 1
0
Clinical risk factors:
(1) large mediastinal mass (>= 33.3% of maximum thoracic diameter)
(2) extra-nodal disease
(3) involvement of >= 3 nodal areas
(4) elevated ESR
(4a) ESR >= 50 mm/h for Stages IA or IIA
(4b) ESR >= 30 mm/h for Stages IB or IIB
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