Distler et al reported criteria for the diagnosis of progression in interstitial lung disease. The authors are from multiple institutions in Europe, the United States and Canada.
Patient selection: interstitial lung disease associated with scleroderma (systemic sclerosis)
Parameters:
(1) decline in FVC in percent, with FVC in liters
(2) decline in DLco in percent, with DLco in mL CO (STPD) per min per mm Hg
The period between baseline and current readings is generally 1-2 years. A decline over a shorter period is more rapid, while a decline over a longer period is slow.
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