Parameters:
(1) serum free kappa light chain in mg/dL prior to therapy
(2) serum free kappa light chain in mg/dL after therapy
(3) serum free lambda light chain in mg/dL prior to therapy
(4) serum free lambda light chain in mg/dL after therapy
(5) serum immunofixation electrophoresis after therapy
(6) urine immunofixation electrophoresis after therapy
difference between involved and uninvolved light chain =
= (involved light chain) - (uninvolved light chain)
decrease in percent =
= ((pretreatment) - (post-treatment)) / (pretreatment * 100%
To measure a decrease the light chain concentration should be >= 50 mg/dL.
Criteria for complete response:
(1) negative serum immunofixation electrophoresis
(2) negative urine immunofixation electrophoresis
(3) normal serum kappa to lambda ratio (from 3:2 to 2:1)
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Difference between involved and uninvolved light chain
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Response
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< 4 mg/dL
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very good partial
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decrease >= 50%
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partial
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decrease < 50%
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no response
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