An international working group was formed to standardize response criteria for therapy of myelodysplastic syndromes (MDS). These included criteria for a complete or partial remission to therapy. The authors are from multiple institutions in Europe and the United States.


Duration of findings: at least 2 months (8 weeks)


Features of a remission (complete or partial) - all of the following:

(1) hemoglobin > 11 g/dL

(2) platelet count > 100,000 per µL

(3) absolute neutrophil count >= 1,500 per µL

(4) no circulating blasts in peripheral blood

(5) no blood product transfusion

(6) no growth factor therapy


Complete Remission

Partial Remission

percentage blasts

< 5% (normal) AND

decreased >= 50% from pretreatment levels OR

evidence of MDS

AND no dysplasia with normal maturation in all cell lines

OR less advanced FAB classification



Percent Erythroid Precursors

Formula for Blast Percent

< 50%

(number blasts) / (100 nucleated cells) * 100%

>= 50%

(number blasts) / (100 nonerythroid cells) * 100%


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