Description

Carson et al developed criteria for the diagnosis of drug-induced pneumonitis associated with methotrexate therapy.


 

Parameters:

(1) clinical course

(2) chest radiograph

(3) pneumonia or other pulmonary disease

(4) histopathology

 

Parameter

Finding

Points

clinical course

inconsistent with hypersensitivity reaction

0

 

consistent with hypersensitivity reaction

1

chest radiograph

no infiltrate

0

 

infiltrate present

1

pneumonia or other pulmonary disease

present

0

 

excluded

1

histopathology

inconsistent with drug-induced injury

0

 

consistent with drug-induced injury

1

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 4

 

Total Score

Diagnosis

4

definite

3

probable

2

possible

0 or 1

unlikely

 


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