Campiotti et al studied patients with chronic myeloid leukemia (CML) who developed blast crisis. The authors are from Clinica Universita dell’Insubria and Ospedale di Circolo Varese in Italy.


Patient selection: chronic myeloid leukemia


Criteria for blast crisis – one or more of the following:

(1) blasts >= 20% of nucleated bone marrow cells

(2) blasts >= 20% of differential count in peripheral blood

(3) extramedullary blast proliferations

(4) large blast islands in the bone marrow



• Alimena et al used counts >= 30% rather than >= 20%.


Criteria for CML blast crisis rather than AML: presence of t(9;22)(q34;q11)


Some patients may initially present in blast crisis, making the distinction from AML more important.


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