Patient selection: papillary thyroid carcinoma
Criteria for progressive disease - 1 or both of the following:
(1) significant increase in serum thyroglobulin concentration
(2) imaging studies (CT or PET scan) abnormal
Another criteria for progression would be tumor identified in a pathology specimen from a new site.
Criteria for cure:
(1) serum thyroglobulin levels
(1a) < 2 ng/mL after withdrawal of L-thyroxine OR
(1b) undetectable on L-thyroxine OR
(1c) < 1 ng/mL after use of recombinant human TSH
(2) no iodine uptake after diagnostic whole body scan (WBS)
(3) normal neck ultrasonography
Criteria for stable disease:
(1) The patient does not meet criteria for cure or progression.
(2) The serum thyroglobulin concentration has been stable.
(3) The tumor volume is stable on imaging studies.
