Bronson reported criteria for determining when to treat an infertile female with antisperm antibodies. The author is from the University of New York in Stony Brook, New York.


Criteria for treatment of immunologic infertility in a female:

(1) infertile female

(2) antisperm antibodies in the serum

(3) impaired post coital test (examination of spermatozoa in cervical mucus), with large numbers of spermatozoa that are immobilized or showing restricted movement

(4) exclusion of other causes of hostile cervical mucus

(4a) occult cervicitis

(4b) altered pH

(4c) poor cervical mucus production

(5) demonstration of antisperm antibodies along the female genital tract (uterotubal washings, vaginal secretions, cervical mucus or peritoneal fluid)


For the implementation I have also added the following:

(6) other causes of infertility have been excluded


NOTE: For a male with antisperm antibodies the sperm is examined for a coating of antibodies. This could also be done on the post-coital sample. The evidence would be stronger if a semen sample collected from the male was negative for antibodies.


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