Braun et al listed criteria for an adequate therapeutic trial of an NSAID in patients with ankylosing spondylitis. The authors are involved in the ASAS (Assessment in Ankylosing Spondylitis) Working Group.
Patient selection: ankylosing spondylitis
Drug: non-steroidal anti-inflammatory drug (NSAID)
Parameters:
(1) duration of trial therapy
(2) dose
(3) contraindications, intolerance or complications (discontinuation for problems)
Duration of Therapy
Dose
Discontinuation
Criteria
>= 3 months
maximum recommended or tolerated
No
1
>= 3 months
maximum recommended or tolerated
Yes
2
> 0 and < 3 months
maximum recommended or tolerated
Yes
3
where:
• Not using an NSAID initially because of contraindication(s) probably should not be counted as a therapeutic trial.
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