Asherson et al listed criteria for the diagnosis of the catastrophic antiphospholipid syndrome (CAPS).
(1) involvement of organs, organ systems or tissues
(2) rapid progression (simultaneously or in less than 1 week)
(3) laboratory demonstration of antiphospholipid antibodies
(4) histologic evidence of small vessel occlusion (may involve 1 or more sites; may be accompanied by vasculitis)
Number of Organs
• Involvement of an organ or tissue may be demonstrated by imaging studies.
• Renal involvement is defined by an increase in serum creatinine by 50% or more, severe arterial hypertension and/or proteinuria.
• Subacute progression may involve progression from 1 to 4 weeks after presentation despite anticoagulation.
• Laboratory evidence may not available if testing was not done or if the patient dies.
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Specialty: Hematology Oncology, Clinical Laboratory, Immunology/Rheumatology