Akhloufi et al identified a number of criteria for switching a patient from intravenous to oral antibiotic therapy. The authors are from Erasmus MC University, Radboud University and Academic Medical Center Amsterdam.

Patient selection: intravenous antibiotic


Criteria for the switch - all of the following:

(1) stable systolic blood pressure

(2) cooperative patient

(3) an adequate antimicrobial concentration is achievable at the site of infection with oral therapy

(4) absence of fever or temperature < 36°C

(5) absence of malabsorption syndrome

(6) absence of short bowel syndrome

(7) absence of severe gastroparesis

(8) absence of ileus

(9) absence of continuous nasogastric suction

(10) absence of vomiting

(11) absence of severe sepsis

(12) absence of necrotizing fasciitis

(13) absence of CNS infection

(14) absence of Staphylococcus aureus bacteremia

(15) absence of endovascular infection

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