Complete hematologic response, or remission (CHR):
(1) normalization for at least 4 weeks
(2) bone marrow with < 5% blasts
(3) peripheral blood leukocyte count < 10,000 per µL without peripheral blasts, promeylocytes or myelocytes
(4) disappearance of all signs and symptoms related to CML
where:
• I assume that disappearance of all signs and symptoms include the platelet count <= 450,000 per µL and there is no clinical splenomegaly.
Partial hematologic response (PHR) - as for complete response except for:
(1) persistence of immature cells (myelocytes, metamyelocytes) in peripheral blood
(2) splenomegaly < 50% of the pretreatment level
(3) thrombocytosis > 450,000 per µL but < 50% of pretreatment level
|
Cytogenetic Response
|
Findings
|
|
complete
|
0% Philadelphia chromosome positive
|
|
partial
|
1-34%
|
|
minimal
|
35-90%
|
|
none
|
100% (> 90%)
|
A partial or complete cytogenetic response was classified as a major cytogenetic response.
