|
Feature Letter
|
Finding
|
|
P
|
polyneuropathy
|
|
O
|
organomegaly, osteosclerotic bone lesions
|
|
E
|
endocrinopathy
|
|
M
|
monoclonal protein (often IgA or IgG lambda)
|
|
S
|
skin changes
|
Polyneuropathy:
(1) progressive sensorimotor polyneuropathy
(2) may resemble Guillain-Barre syndrome
Organomegaly:
(1) hepatomegaly
(2) splenomegaly
(3) generalized lymphadenopathy
Endocrinopathies found:
(1) hypothyroidism
(2) diabetes mellitus
(3) hypogonadism
(4) impotence
(5) gynecomastia (males)
(6) amenorrhea (females)
(7) adrenal insufficiency
Skin changes:
(1) hyperpigmentation (most common finding)
(2) sclerodermoid skin changes with skin thickening
(3) hypertrichosis
(4) digital clubbing
(5) edema
(6) angiomas, especially the glomeruloid hemangioma
(7) nail changes (leukonychia, Terry nails)
(8) acquired ichthyosis
(9) multiple seborrheic keratoses
(10) livedo reticularis
(11) purpura
(12) ulcers
(13) flushing
(14) Raynaud's phenomenon
Other findings that may occur:
(1) polycythemia or anemia
(2) leukocytosis
(3) thrombocytosis
(4) cutaneous infarction
(5) papilledema
(6) pleural effusions and/or ascites
