Criteria for the Neuroleptic Malignant Syndrome (NMS) have been published in the Diagnostic and Statistical Manual of Mental Disorders (DSM).

Criteria for the neuroleptic malignant syndrome - all of the following:

(1) all of the following:

(1a) severe muscle rigidity

(1b) elevated temperature

(1c) use of neuroleptic medications

(2) 2 or more of the following:

(2a) diaphoresis

(2b) dysphagia

(2c) tremor

(2d) incontinence

(2e) altered level of consciousness

(2f) mutism

(2g) tachycardia

(2h) elevated or labile blood pressure

(2i) leukocytosis

(2j) elevated serum CK or other marker of skeletal muscle injury

(3) exclusion of other possible explanations

(3a) other drugs or chemicals

(3b) infection (viral encephalitis)

(3c) neurologic disorder

(3d) mental disorder (catatonia)

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