Criteria for the Diagnosis of Hereditary Diffuse Gastric Cancer

 

Inheritance: autosomal dominant

 

Parameters:

(1) number of close family members with gastric cancer

(2) youngest age of onset

(3) histologic features

Number of Affected Relatives in Family	Youngest Age	Histologic Features of Gastric Cancer
>= 1	< 35 years	diffuse
>= 2	< 50 years	tumor in person < 50 years of age diffuse
>= 3	NA	at least 1 diffuse
>= 2	NA	diffuse

from page 2361

 

where:

• Any patient being evaluated is included in the familial count.

 

Some kindreds have gastric cancer only while others will have cancers in other organs (breast, etc). In one group of families studied by Kaurah et al the risk of breast cancer (usually lobular type) in woman carriers was about 50%.