Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) is a designation proposed to replace the term Hypersensitivity Syndrome. This syndrome involves a severe idiosyncratic reaction to a drug, with a severe cutaneous eruption, fever, lymphadenopathy, and involvement of multiple organs. If unrecognized, the process can be fatal in 10% of patients, while drug cessation and corticosteroid therapy can result in clinical improvement.

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