Clinical activity:
(1) progression
(2) regression
(3) fluctuating
Although not listed, stable disease is another disease state that needs to be included.
Bleeding:
(1) acute
(2) chronic
Criteria for progression - one of the following:
(1) de novo appearance
(2) change in endoscopic lesions from mild to severe during followup
Criteria for regression - one of the following:
(1) disappearance
(2) change in endoscopic lesions from severe to mild during followup
Criteria for fluctuating course - alternating between mild and severe during subsequent visits. I would think that reappearance of lesions would qualify.
Criteria for stable disease - same state during subsequent visits
Criteria for acute bleeding - both of the following:
(1) hematemesis or melena
(2) actively bleeding gastric lesion
Criteria for chronic bleeding - all of the following:
(1) decrease in hemoglobin >= 2 g/dL over 6 months
(2) no active bleeding episodes
(3) no intake NSAIDs
I added a criteria for chronic bleeding in the implementation to exclude another source of bleeding.
