Patient < 12 Months of Age
Criteria for certain or probable:
(1) increase in AST, ALT and ammonia levels
(2) increase in AST, ALT or ammonia >= 3 fold rise
(3) total bilirubin < 51 µmol/L
(4) hepatic steatosis
(5) no other obvious explanation for the acute illness
Additional criteria for certain:
(1) organic acid levels compatible with Reye's syndrome
(2) normal serum carnitene level
(3) mitochondrial alterations compatible with Reye's syndrome
Patient >= 12 Months of Age
Criteria for certain or probable:
(1) increase in AST, ALT and ammonia levels
(2) increase in AST, ALT or ammonia >= 3 fold rise
(3) total bilirubin < 51 µmol/L
(4) hepatic steatosis
(5) no other obvious explanation for the acute illness
(6) clinical history consistent with Reye's syndrome: a prodromal illness was followed by protracted vomiting with or without progressive alteration of consciousness
Additional criteria for certain:
(1) mitochondrial alterations compatible with Reye's syndrome
