Certain clinical and imaging findings can identify a spleen that is involved by malignant lymphoma. The criteria were developed at the 12th International Conference (2013) for Malignant Lymphoma in Lugano, Switzerland.

Patient selection: malignant lymphoma, Hodgkin's or non-Hodgkin's disease



(1) findings on physical examination

(2) findings on appropriate imaging study


If the lymphoma shows FDG ([18F]-fluorodeoxyglucose) avidity (based on histology) then PET-CT imaging is performed, else CT.


Criteria for splenic involvement:

(1) palpable spleen

(2) positive imaging findings


Findings on PET-CT Scan

Findings on CT Scan

diffuse FDG uptake

> 13 cm in vertical length

solitary mass

solitary mass

miliary lesions

miliary lesions




The diagnostic certainty increases if other causes of splenic enlargement or increased FDG uptake are excluded.

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