Some cases of chronic lymphocytic leukemia progress very slowly and are termed "smoldering". These cases may be recognized if certain criteria are present.
Parameter
Finding
Binet's stage
A
bone marrow involvement
nondiffuse lymphocytic infiltration
lymphocytic doubling time
> 12 months
blood lymphocyte count
<= 30,000 per µL
hemoglobin
>= 13 g/dL
Calculating the Doubling Time for the Absolute Lymphocyte Count
(difference between 2 counts per µL) / (number of months between counts) =
= (initial lymphocyte count per µL) / (doubling time in months)
doubling time in months =
= (initial lymphocyte count per µL) * (number of months between counts) / (difference between second and initial lymphocyte counts per µL)
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