De et al reported criteria for identifying a patient with severe alcoholic hepatitis. This can help to identify a patient at greater risk for complications. The authors are from the Medical College & Hospitals of Calcutta.
Parameters:
(1) daily alcohol intake in grams per day
(2) Maddrey discriminant function (DF)
(3) serum aspartate aminotransferase (AST, SGOT) in IU/L
(4) serum alanine aminotransferase (ALT, SGPT) in IU/L
ratio of AST to ALT =
= (serum AST) / (serum ALT)
Criteria for severe alcoholic hepatitis:
(1) history of chronic alcohol intake of > 50 grams per day
(2) Maddrey DF >= 32
(3) AST to ALT ratio > 2
(4) AST < 500 IU/L and ALT < 200 IU/L
where:
• Alcohol intake is not adjusted for gender.
Ideally other causes of chronic liver disease should be excluded.
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