Criteria of Calin et al for Reiter's Syndrome:
(1) seronegative (rheumatoid factor negative) asymmetric arthropathy predominantly affecting the lower extremity. Usually this is a polyarthropathy but may be a monoarthropathy.
(2) one or more of the following:
(2a) urethritis, or cervicitis in women
(2b) dysentery
(2c) inflammatory eye disease (conjunctivitis, iridocyclitis, uveitis)
(2d) mucocutaneous disease (balanitis in the male, oral ulcerations, and/or keratodermia)
(3) none of the following
(3a) primary ankylosing spondylitis
(3b) psoriatic arthropathy
(3c) other rheumatic diseases
Other findings:
(1) nail lesions
(2) aortitis
(3) tendinitis
Associations:
(1) Infection with Chlamydia trachomatis can be found in over 70% of men with untreated nondiarrheal Reiter's syndrome.
(2) There is evidence of exaggerated cell-mediated and humoral responses to chlamydial antigens.
(3) A similar syndrome may occur after enteric infection with Salmonella, Shigella or Campylobacter.
(4) HLA-B27 is present in over 80% of affected patients.
