Synonyms: ischemia-reperfusion injury, early graft dysfunction, re-implantation response
The process appears around 24 hours after surgery, reaches maximum severity at 3 or 4 days, then improves by the end of the first week after the transplant.
Risk factors:
(1) surgical trauma
(2) donor lung ischemia
(3) interruption of the bronchial circulation
(4) interruption of lymphatic flow
Clinical features:
(1) noncardiogenic pulmonary edema with diffuse pulmonary infiltrate
(2) severe hypoxemia
The diagnosis requires exclusion of other causes.
Complications:
(1) increased perioperative mortality
(2) decreased long-term survival
(3) progression to bronchiolitis obliterans syndrome (BOS)
