The response of a patient with malignant lymphoma can be classified based on criteria that were presented at the 12th International Conference (2013) for Malignant Lymphoma in Lugano, Switzerland.

Patient selection: malignant lymphoma, Hodgkin's or non-Hodgkin's disease


A partial response may be classified based on:

(1) PET-CT based response, also known as the metabolic response

(2) CT based response, also referred to as the radiologic response


The PET-CT scan would not be relevant if the lymphoma did not show FDG-avidity.


Criteria for a partial PET-CT based response - all of the following:

(1) FDG uptake with score 4 or 5 on 5-PS at the end of treatment but reduced compared to baseline

(2) none or residual FDG uptake in bone marrow but reduced compared to baseline

(3) no new lesions



FDG uptake before the end of treatment can be seen in responding tumor.

Diffuse uptake in the bone marrow may reflect reactive change to chemotherapy.


Criteria for a partial CT based response - all of the following:

(1) >= 50% decrease in the sum of the perpendicular products (SPD) in up to 6 measurable nodal and/or extranodal sites

(2) smaller lesions (not measured for SPD) are regressed or absent AND not increased

(3) if spleen was enlarged then length must have decreased > 50%

(4) no new lesions



Assessment of bone marrow was designated not applicable to radiologic response.

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