Description

Criteria for the diagnosis of microscopic polyangiitis (mPAN) were proposed at an International Consensus Conference held at the University of North Carolina, Chapel Hill, North Carolina.


Lesion: necrotizing vasculitis with few or no immune deposits

 

Vessel

Involvement

venules

yes

capillaries

yes

arterioles

yes

small arteries

possibly

medium-sized arteries

possibly

large arteries

no

 

Common findings:

(1) necrotizing glomerulonephritis

(2) pulmonary alveolar capillaritis

(3) presence of pANCA or cANCA

 

Polyarterteritis nodosa is distinguished by:

(1) absence of glomerulonephritis

(2) absence of vasculitis involving arterioles, capillaries and venules

 

Other forms of small vessel vasculitis are distinguished by:

(1) more than a few immune deposits


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