Certain clinical and imaging findings can identify a body site involved by malignant lymphoma. The criteria were developed at the 12th International Conference (2013) for Malignant Lymphoma in Lugano, Switzerland.

Patient selection: malignant lymphoma, Hodgkin's or non-Hodgkin's disease


Some of the "other" sites that can be involved by lymphoma include:

(1) skin

(2) bone marrow

(3) bone

(4) lung

(5) heart

(6) gastrointestinal tract


If the lymphoma shows FDG ([18F]-fluorodeoxyglucose) avidity (based on histology) then PET-CT imaging is performed, else CT.


Criteria for lymphomatous involvement:

(1) signs and symptoms relevant to site

(2) increased FDG uptake on PET-CT scan if FDG-avid

(3) nodules or mass lesions on imaging studies

(4) biopsy shows lymphoma based on morphology and flow cytometry


The diagnostic certainty increases if other causes of lymph node enlargement or increased FDG uptake are excluded.

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