Reye's Syndrome can be excluded or considered unlikely if certain criteria are met.


Reye's Syndrome can be considered excluded if one or more of the following findings are present:

(1) normal AST and ALT

(2) no necrosis and inflammation on liver biopsy

(3) no steatosis on liver biopsy

(4) no significant mitochondrial alterations seen on electron microscopy

(5) a cause for the acute illness can be identified


Reye's syndrome is considered unlikely if:

(1) the case has not already been classified as certain, probable or excluded, OR if

(2) two or more of the following are present

(2a) total bilirubin level >= 51 µmol/L

(2b) normal serum ammonia level, if stage 2 or greater

(2c) a threefold or greater increase in creatinine level

(2d) focal neurologic signs are present

(2e) myocardial damage is present

(2f) no prodromal illness present if >= 12 months of age

(2g) shock present on admission

(2h) CSF protein level >= 0.5 g/L


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