Signs and symptoms of early congenital syphilis:
(1) rhinitis with nasal discharge
(2) mucocutaneous lesions (bullae, vesicles, superficial desquamation, petechiae, papulosquamous lesions, mucous patches, and condylomata lata)
(3) bony lesions (osteochondritis, osteitis, periostitis)
(4) hepatosplenomegaly and lymphadenopathy
(5) hematologic (anemia, thrombocytopenia, leukocytosis)
Criteria for Definitive Diagnosis - one or more of the of the following:
(1) demonstration of T. pallidum by direct microscopic examination of material from umbilical cord
(2) demonstration of T. pallidum by direct microscopic examination of placenta
(3) demonstration of T. pallidum by direct microscopic examination of nasal discharge
(4) demonstration of T. pallidum by direct microscopic examination of skin lesion material
Criteria for Presumptive Diagnosis:
(1) determination that the infant was born to a mother who had untreated or inadequately treated syphilis at delivery regardless of findings in infant
AND
(2) infant has a reactive treponemal test result
AND
(3) one or more of the following
(3a) clinical signs or symptoms of congenital syphilis on physical examination
(3b) abnormal CSF findings without other feasible cause
(3c) reactive VDRL CSF result
(3d) reactive IgM antibody test specific for syphilis
