Patient selection: malignant lymphoma, Hodgkin's or non-Hodgkin's disease
A complete response may be classified based on:
(1) PET-CT based response, also known as the metabolic response
(2) CT based response, also referred to as the radiologic response
The PET-CT scan would not be relevant if the lymphoma did not show FDG-avidity.
Criteria for a complete PET-CT based response - all of the following:
(1) FDG uptake with one of the following:
(1a) score <= 3 on 5-PS with or without residual mass
(1b) uptake at sites with high physiological uptake or after drug-induced activation less than or equal to that of surrounding normal tissue
(2) negative FDG-uptake in bone marrow
(3) no new lesions
Criteria for a complete CT based response - all of the following:
(1) maximum diameter of target node or nodal mass <= 1.5 cm
(2) no extranodal sites
(3) normal size of previously enlarged organ(s)
(4) normal bone marrow with negative immunohistochemistry
(5) no new lesions
