Worsening of a patient with primary sclerosing cholangitis (PSC) may be detected by changes in clinical or biochemical findings.


Criteria for clinical and biochemical worsening in a patient with PSC: one or more of the following:

(1)unintentional weight loss > 10 pounds during the past 12 months

(2) increase in serum total bilirubin level by > 2 mg/dL (excluding episodes of cholangitis)

(3) new onset of variceal bleeding

(4) new onset of ascites

(5) new onset of encephalopathy


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