Certain clinical and imaging findings can identify central nervous system (CNS) involvement by malignant lymphoma. The criteria were developed at the 12th International Conference (2013) for Malignant Lymphoma in Lugano, Switzerland.

Patient selection: malignant lymphoma, Hodgkin's or non-Hodgkin's disease


Criteria for CNS involvement:

(1) signs and symptoms of CNS disease (headache, altered level of consciousness, etc)

(2) cerebrospinal fluid showing lymphoma on cytology and flow cytometry

(3) mass lesions on CT and/or MRI

(4) leptomeningeal infiltration on MRI


The diagnostic certainty increases if other causes of splenic enlargement or increased FDG uptake are excluded.

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