Brief Resolved Unexplained Events (BRUE) is a term that has replaced Apparent Life-Threatening Event (ALTE). The goal was to make a more specific term that would improve diagnosis and management.


Criteria for BRUE:

(1) infant less than 1 year old

(2) brief (less than 1 minute)

(3) resolved (return to baseline state of health)

(4) normal appearance and normal vital signs at the time of medical evaluation

(5) the event featured one or more of the following:

(5a) central cyanosis or central pallor

(5b) abnormal breathing (absent/apnea, decreased, and/or irregular)

(5c) marked change in muscle tone (hypertonia or hypotonia)

(5d) altered level of responsiveness (lethargy, loss of consciousness, somnolence)

(6) no explanation is found after an appropriate history and physical exam


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