CRC-PRO Calculator of Wells et al for Colorectal Cancer: Nomogram for Males

Patient selection: adult male from 45 to 80 years of age

 

Parameters:

(1) age in years

(2) ethnicity

(3) pack years of smoking

(4) number of alcoholic drinks per day

(5) body mass index (BMI)

(6) years of education

(7) regular use of aspirin

(8) family history of colon cancer

(9) regular use of multivitamins

(10) ounces of red meat eaten per day

(11) diabetes

(12) hours of moderate physical activity per day

 

Parameters	Finding	Points
ethnicity	white	0
	Latino	1.5
	black	6.7
	Hawaiian	13.5
	Japanese	17.6
aspirin	yes	0
	not currently	7.3
	no	8.8
family history	no	0
	yes	10.2
multivitamins	yes	0
	no	8.8
diabetes	no	0
	yes	4.4

 

points for age over range from 45 to 80 years =

= (-0.02936*((age)^2)) + (6.5059 * (age)) - 233.26

 

points for moderate physical activity per day over range from 0 to 2 hours =

= (0.586 * ((hours)^2)) - (3.9589 * (hours)) + 5.5718

 

points for BMI over range from 20 to 35 kg per square meter =

= (0.03079 * ((BMI)^2)) - (0.69941 * (BMI)) + 1.5469

 

points for years of education over range from 8 to 12 =

= (-0.21994 * ((years)^2)) + (6.5982 * (years)) - 38.71

 

points for years of education from 14 to 16 years =

= 29.4 - (1.45 * (years))

 

points for pack years of smoking over range from 0 to 50 =

= (0.0035 * ((years)^2)) + (0.086 * (years)) - 0.27

 

points for alcoholic drinks per day over range from 0 to 2=

= (6.085 * (drinks))

 

points for alcoholic drinks per day over range from 2 to 12=

= (0.73313 * (drinks)) + 10.447

 

points for red meat over range from 0 to 2 ounces per day =

= (2.7859 * (ounces)) - 0.0953

 

points for red meat over range from 2 to 4 ounces per day =

= (0.58651 * (ounces)) + 4.3988

 

Overages	Use
physical activity > 2 hours	0
BMI over 35	14.7
BMI under 20	0
drinks over 12	19.4
red meat over 4 ounces	6.7
education over 16 years	6.2
pack years over 50	12.6

 

total score =

= SUM(points for all 12 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 210

 

Total Score	10 year risk of colorectal cancer in percent
0 to 188	10^((0.010583*(score))-0.79253)
> 188	> 15%