CRAB is an acronym for 4 common features seen in multiple myeloma.

C: hypercalcemia

R: renal insufficiency

A: anemia

B: bone lesions


Talamo et al list 10 non-CRAB symptoms that can occur in myeloma:

(1) neuropathy

(2) extramedullary involvement

(3) hyperviscosity syndrome

(4) amyloidosis

(5) coagulopathy

(6) fever, weight loss or other systemic symptoms

(7) plasma cell leukemia

(8) infections

(9) cryoglobulinemia

(10) secondary gout

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