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Correcting the Measured Serum Sodium for the Amount of Plasma or Serum Water in a Patient with Increased Lipid or Protein Concentrations

Specialty:

Endocrinology, Nutrition & Dermatology
Clinical Laboratory

Objective:

ICD-10:

Description:

Patients with increased concentrations of lipid or protein in the blood will have proportionately less water present in a given volume. This means that electrolytes and other compounds distributed in water will appear to be at a lower concentration than they are physiologically. While this classically presents as pseudohyponatremia, it may mask hypernatremia (pseudonormonatremia).

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