Page et al reported the Cord Blood Apgar (CBA) to evaluate a banked cord blood sample. There are precryopreservation, post-thaw and composite scores. The authors are from Duke University, EMMES Corporation, Aldagen, Inc. and Cicada Biopharmaceutical Consulting.
Specimen selection: cord blood specimen, prior to cryopreservation
Parameters:
(1) colony forming units (CFUs) in 10^4
(2) total nucleated cells (TNCs) in 10^7
(3) CD34+ cells in 10^5
(4) volume collected in mL
(5) body weight of recipient in kg
CFUs in 10^4/kg =
= (CFSs in 10^4) / (body weight)
TNCs in 10^7/kg =
= (CFSs in 10^7) / (body weight)
CD34+ cells in 10^5/kg =
= (CFSs in 10^5) / (body weight)
Parameters
Findings
Points
CFUs in 10^4/kg
> 36.8
4
19.01 to 36.8
3
11.02 to 19.0
2
<= 11.01
1
TNCs in 10^7/kg
> 11.1
2
6.91 to 11.1
1.5
4.11 to 6.9
1
<= 4.1
0.5
CD34+ in 10^5/kg
>3.7
2
2.21 to 3.7
1.5
1.21 to 2.2
1
<= 1.2
0.5
volume in mL
> 125
1
100.1 to 125
0.75
80.1 to 100
0.5
<= 80
0.25
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 2.25
• maximum score: 9
• The higher the score the better the neutrophil engraftment.
Score
Quartile
>= 7.75
first (highest)
5.51 to 7.74
second
4.26 to 5.50
third
<= 4.25
fourth
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