Certain mushrooms can cause a disulfiram-like reaction following ingestion of alcohol. The toxin inhibits aldehyde dehydrogenase, resulting in an accumulation of acetaldehyde.
Mushrooms involved:
(1) Coprinus species (C. atramentarius, others)
(2) Clitocybe claviceps
Group in the POISINDEX classification: V
Toxin: coprine (a cyclopropanone-glutamine adduct), whose active form is l-aminocyclopropanol
Onset: <= 30 minutes after ingestion of alcohol
Clinical symptoms that occur only after alcohol is ingested:
(1) facial flushing
(2) swelling and tingling of hands
(3) nausea and vomiting
(4) palpitations and chest pain
(5) tachycardia
(6) metallic taste
(7) headache
(8) vertigo
(9) sweating
(10) muscle fasciculations
(11) agitation
(12) hypotension
The effect may persist for several days after the mushrooms were eaten (from 2 to 5 days).
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