Intravenous immune globulin (IVIG) is usually given IV every 3 to 4 weeks. Subcutaneous immune globulin (SCIG) can be given subcutaneously weekly.


Product: Vivaglobin (CSL Behring)


The drug is infused by a syringe pump into multiple subcutaneous sites at the same time. The maximum rate of infusion is 20 mL per hour, or 45 minutes for 15 mL.


Steps in dose conversion:

(1) Multiply the IVIG dose in mg by 1.37 to get the equivalent SCIG dose in mg.

(2) Divide the total dose by the dosing interval in weeks to get the average weekly dose.

(3) SCIG has a dose concentration of 160 mg IgG per mL. The number of mL to inject = (total weekly dose) / 160.

(4) A maximum of 15 mL can be injected at one site. The number of sites to use = ROUNDUP((volume in mL) / 15).

(5) The volume to inject at each site = (total weekly volume in mL) / (number of sites).


Sites used for the infusion:

(1) upper arm

(2) lateral hip

(3) lateral thigh

(4) abdomen


Each site should be at least 2 inches (5 cm) apart.


If a patient is starting immune globulin therapy, the dose of vivaglobin is 100-200 mg per kg body weight per week (probably using ideal body weight).


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