Thrombolytic therapy can have serious complications in certain clinical conditions. When these conditions occur, thrombolytic therapy should either not be used or else used only with extreme caution.


Complications of thrombolytic therapy:

(1) hemorrhage, including intracerebral hemorrhage

(2) embolic phenomenon from dissolved thrombotic material

(3) anaphylactic response to thrombolytic agent used





active internal bleeding


cerebrovascular accident (CVA) or other active intracranial process within past 2 months


history of anaphylaxis to thrombolytic agent used

relative major

major surgery within past 10 days


recent obstetric delivery


recent organ biopsy


recent puncture of noncompressible blood vessel


recent serious gastrointestinal bleeding


recent serious trauma


severe hypertension (systolic blood pressure > 200 mm Hg; diastolic blood pressure > 110 mm Hg)

relative minor

recent minor trauma (including CPR)


high likelihood of thrombus in left heart


bacterial endocarditis


diabetic hemorrhagic retinopathy




age > 75 years



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