Thrombolytic therapy can have serious complications in certain clinical conditions. When these conditions occur, thrombolytic therapy should either not be used or else used only with extreme caution.
Complications of thrombolytic therapy:
(1) hemorrhage, including intracerebral hemorrhage
(2) embolic phenomenon from dissolved thrombotic material
(3) anaphylactic response to thrombolytic agent used
|
Contraindication |
Condition |
|
absolute |
active internal bleeding |
|
|
cerebrovascular accident (CVA) or other active intracranial process within past 2 months |
|
|
history of anaphylaxis to thrombolytic agent used |
|
relative major |
major surgery within past 10 days |
|
|
recent obstetric delivery |
|
|
recent organ biopsy |
|
|
recent puncture of noncompressible blood vessel |
|
|
recent serious gastrointestinal bleeding |
|
|
recent serious trauma |
|
|
severe hypertension (systolic blood pressure > 200 mm Hg; diastolic blood pressure > 110 mm Hg) |
|
relative minor |
recent minor trauma (including CPR) |
|
|
high likelihood of thrombus in left heart |
|
|
bacterial endocarditis |
|
|
diabetic hemorrhagic retinopathy |
|
|
pregnancy |
|
|
age > 75 years |
Specialty: Hematology Oncology, Clinical Laboratory, Pharmacology, clinical
ICD-10: ,
