Absolute contraindications:
(1) coagulopathy that would be uncontrollable if receiving heparin
(2) mechanical ventilation for > 7 days
(3) PaO2 to FIO2 ratio < 100 for > 5 days
(4) 3 or more major organ system failures
(5) pre-existing chronic severe lung disease
(6) terminal illness with short life expectancy
(7) end-stage HIV disease
(8) uncontrolled metabolic acidosis
Relative contraindications:
(1) anti-heparin antibodies (an alternative anticoagulant could be used)
(2) HIV disease
(3) septic shock
(4) severe pulmonary hypertension
(5) immunosuppression
(6) severe CNS disease
(7) severe and irreversible heart disease
where:
• With HAART HIV disease has become more of a chronic disease. People with well-controlled disease may have near-normal survivals.
