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Treatment Outcome - B-Type Natriuretic Peptide - (BNP) and Severe Congestive Heart Failure (CHF)

Purpose: To evaluate a patient hospitalized with severe congestive heart failure using clinical status and B-type natriuretic peptide (BNP) levels.

Description

The outcome for patients hospitalized with New York Heart Association (NYHA) Class III and IV heart failure following therapy can be predicted using the clinical status and B-type natriuretic peptide (BNP) serum level. The authors are from the University of California in San Diego.


 

Adverse outcomes used as endpoints for study:

(1) early readmission after discharge (within 30 days)

(2) death

 

Assay for B-type natriuretic peptide: Triage B-type natriuretic peptide test (Biosite Diagnostics, Inc.; San Diego, California).

 

Outcome

Clinical Status

BNP Level

successful treatment

improvement (to NYHA Class I or II)

decrease (from 800 – 1,100 pg/mL on admission to 500-800 pg/mL)

early readmission

some improvement

essentially unchanged (from 1,200 – 1,800 pg/mL on admission to 1,000 – 2,000 pg/mL)

death

no or minimal improvement with therapy

increase (from 1,200 – 1,800 pg/mL on admission to 1,600-2,400 pg/mL)

after Figure 1, page 388

 

Limitations:

• There are several different assays for BNP. If an alternative assay is used, the levels of BNP need to be adjusted.

 


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Specialty

Objective

ICD-10