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Description

Angioedema needs to be distinguished from other conditions that can cause localized or generalized swellings.


 

Allergic reactions:

(1) contact dermatitis

(2) poison ivy, poison oak or other Rhus-containing plants

 

Immune disorders:

(1) acquired C1-inhibitor deficiency syndrome

(2) autoantibodies (hypocomplementemic urticarial vasculitis syndrome)

(3) Crohn's disease (affecting the lower lip)

(4) tumor necrosis factor receptor-associated periodic syndrome (TRAPS)

(5) Weber-Christian disease (febrile, nonsuppurative panniculitis)

 

Edema:

(1) acute idiopathic scrotal edema

(2) dependent edema

(3) superior vena cava syndrome

(4) severe protein malnutrition

(5) Clarkson's syndrome (idiopathic capillary leak syndrome)

 

Infiltrative disorders:

(1) systemic amyloidois

(2) scleromyxedema

(3) thyroid orbitopathy in Grave's disease

(4) Well's disease (skin plaques with eosinophilia)

(5) Shulman's syndrome (eosinophilic fasciitis)

(6) Melkersson-Rosenthal syndrome (noncaseating granulomas in the lips)

 

Infections:

(1) cellulitis

(2) parasite infections (trichinosis, Loa Loa, trypanosomiasis)

(3) viral infection

 

Physical injury:

(1) trauma

(2) thermal burns

(3) chemical burns

 

Miscellaneous:

(1) blepharochalsis (relaxation of eyelid skin)

 


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