Ochronosis refers to a discoloration of connective tissue (cartilage, tendons, sclera). While a hallmark of alkaptonuria it may also be seen in other conditions.
Conditions associated with ochronosis:
(1) long term therapy with Atabrine (Quinacrine HCl, an antihelminthic and antimalarial agent)
(2) carbolic acid dressings for chronic cutaneous ulcers
(3) long term use of hydroquinone in topical creams and lotions
(4) melanosis associated with melanoma
The first 3 conditions will revert upon discontinuation of the causative agent.
These patients should have normal levels of homogentisic acid in the serum and urine.
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