Xanthomas can arise as a result of a number of conditions.

Hereditary disorders:

(1) familial hypercholesterolemia (FH)

(2) familial dysbetalipoproteinemia

(3) sitosterolemia

(4) cerebrotendinous xanthomatosis (CTX)


Acquired in association with hyperlipidemia:

(1) thyroid disease

(2) diabetes mellitus

(3) pancreatitis (especially with chylomicronemia)

(4) obstructive liver disease

(5) paraneoplastic

(6) other hyperlipidemia


Other acquired:

(1) localized phenomenon without systemic disorder

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