A splenic infarct can occur in many conditions.
Cardioembolic:
(1) atrial fibrillation
(2) endocarditis
(3) left ventricular thrombus (post-AMI, other)
(4) mitral or aortic valve disease
Vascular disease:
(1) aortic, celiac or splenic atherosclerosis
(2) arterial dissection
(3) aneurysm of the splenic artery
(4) aortic aneurysm
Hematologic/Oncologic disorder:
(1) myeloproliferative disorder
(2) myelodysplasia
(3) leukemia
(4) lymphoma
(5) solid tumor
(6) sickling hemoglobinopathies
(7) polycythemia
(8) autoimmune hemolytic anemia
(9) paroxysmal nocturnal hemoglobinuria
Infection:
(1) malaria
(2) sepsis
(3) varicella zoster
(4) infectious mononucleosis
(5) intra-abdominal abscess
(6) peritonitis
(7) Rickettsial disease
(8) CMV
(9) brucellosis
Hypercoagulable state:
(1) antiphospholipid antibody
(2) lupus anticoagulant
(3) TTP
(4) nephrotic syndrome
(5) heparin-induced thrombocytopenia
Autoimmune disease:
(1) SLE
(2) Wegener's granulomatosis
Intra-abdominal inflammation:
(1) pancreatitis
(2) ischemic colitis
(3) nonischemic colitis
Miscellaneous:
(1) trauma
(2) postoperative, especially intra-abdominal
(3) cirrhosis
(4) transarterial chemoembolization of hepatocellular carcinoma
(5) cocaine use
(6) Gaucher's disease
