A number of conditions may be associated with abnormal loss of magnesium in the urine (magnesium wastage).
Drugs associated with magnesium wastage:
(1) diuretics
(2) aminoglycosides
(3) amphotericin B
(4) calcineurin inhibitors (cyclosporine, tacrolimus)
(5) epidermal growth factor receptor (EGFR) inhibitors (cetuximab)
(6) cytotoxic drugs (cisplatin, carboplatin)
Other conditions associated with magnesium wastage:
(1) alcohol abuse
(2) diabetes
(3) hyperthyroidism
(4) hyperparathyroidism
(5) other causes of hypercalcemia
The fractional excretion of magnesium is increased in patients with renal-wasting of magnesium.
