Pseudo-Kaposi sarcoma (PKS) can occur with a number of conditions. While the lesions may grossly resemble Kaposi's sarcoma, the histologic features differ.
The gross appearance may include:
(1) brown macules
(2) purplish or violaceous nodules
(3) purplish or violaceous plaques
(4) verrucous lesions
(5) cutaneous ulcerations
Histologic Finding
PKS
Kaposi sarcoma
vascular slits
absent
present
CD34
absent
present
Factor VIII antigen
present
absent
Congenital conditions associated with PKS:
(1) Stewart-Bluefarb syndrome (with congenital arteriovenous malformation)
Acquired conditions associated with PKS:
(1) chronic venous insufficiency
(2) amputation stump
(3) adjacent to arteriovenous fistulas created for hemodialysis
(4) paralyzed extremity
(5) trauma
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