Description

Hypercalcemia may occur for a number of reasons. It may be transient or progressive.


 

Transient - dehydration with hemoconcentration

 

Parathyroid related, with hyperparathyroidism:

(1) parathyroid hyperplasia

(2) parathyroid adenoma

(3) parathyroid carcinoma

(4) familial hyperparathyroidism

(5) MEN 1 or 2 (familial multiple endocrine neoplasia)

 

Cancer-related:

(1) multiple myeloma

(2) metastatic carcinoma

(3) malignant lymphoma with excess production of 1,25-dihydroxyvitamin D

(4) VIPoma (vasoactive intestinal polypeptide)

(5) other paraneoplastic (parathyroid hormone like peptide, growth factors, cytokines, etc)

 

Endocrinopathy:

(1) hyperthyroidism

(2) hypothyroidism

(3) acromegaly

(4) adrenal insufficiency

(5) pheochromocytoma

 

Granulomatous disease:

(1) sarcoidosis

(2) tuberculosis

(3) coccidioidomycosis

(4) berylliosis

(5) leprosy

 

Drug, toxic or nutrition associated:

(1) lithium

(2) thiazide diuretics

(3) vitamin A overdose

(4) vitamin D overdose

(5) hyperalimentation regimen

(6) milk-alkali syndrome

(7) foscarnet

(8) testosterone

(9) estrogens or anti-estrogens

(10) aluminum intoxication in chronic renal failure

 

Renal:

(1) familial hypocalcuric hypercalcemia

(2) acute renal failure

(3) chronic renal failure (typically with secondary hyperparathyroidism)

(4) post renal transplant

 

Miscellaneous:

(1) idiopathic hypercalcemia of infancy

(2) immobilization (with osteoporosis)

(3) specimen or laboratory error

 


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