Alacrima is the absence of tears. While acquired hypoproduction is relatively common, hereditary causes of alacrima are rare.
Alacrima accompanied by achalasia:
(1) achalasia, Addison's, alacrima syndrome (AAAS, Allgrove Syndrome)
(2) alacrima, achalasia, mental retartdation (AAMR)
(3) mental retardation, X-linked (MRXS17)
With autonomic neuropathy:
(1) hereditary sensory and autonomic neuropathy (HSAN1B)
(2) HSAN3
(3) HSAN6
Aplasia of the lacrimal glands:
(1) aplasia of the lacrimal and salivary glands (ALSG)
(2) lacrimal-auricular-dental-digital (LADD)
Multi-system disorders
(1) NGLY1 (N-glycanase 1) deficiency
(2) peripheral demyelinating neuropathy, central demyelination, Waardenburg syndrome, Hirschsprung's disease (PCWH)
Facial developmental disorder with neurologic impairment
(1) Schinzel-Giedion midface retraction syndrome
Alacrima with lacrimal glands and absence of other findings:
(1) isolated familial alacrima, autosomal recessive
(2) isolated familial alacrima, autosomal dominant
Other:
(1) Riley-Day syndrome (familial dysautonomia)
(2) anhidrotic ectodermal dysplasia
